httk 2.4.0 (2024-8-14)

This release accompanies the submission of the new manuscript “Enabling Transparent Toxicokinetic Modeling for Public Health Risk Assessment” and includes changes intended to better faciliate development of new HTTK models through improved model clarity.

In addition we have incorporated comments received on manuscript “Impact of Gut Permeability on Estimation of Oral Bioavailability for Chemicals in Commerce and the Environment” provided by reviewers at ALTEX.

Bug Fixes

Enhancements

httk 2.3.1 (2024-3-19)

This patch addresses a number of bugs.

Bug Fixes

Enhancements

httk 2.3.0 (2023-12-05)

This version accompanies the submission of manuscript Honda et al.  “Impact of Gut Permeability on Estimation of Oral Bioavailability for Chemicals in Commerce and the Environment”. Find the analysis scripts on GitHub

Bug Fixes

New Features

Enhancements

httk 2.2.2 (2023-02-20)

Bug Fixes

New Features

Enhancements

httk 2.2.1 (2022-09-24)

This minor update removes UTF-8 characters from the package and changes the calculation of kUrt on line 292 of model_gas_pbtk.c to reduce vulnerability to machine precision errors.

httk 2.2.0 (2022-09-08)

This version accompanies the submission of the Breen et al. manuscript “Simulating Toxicokinetic Variability to Identify Susceptible and Highly Exposed Populations”

Enhancements

Bug Fixes

httk 2.1.0 (2022-03-26)

This version accompanies the submission of the Kapraun et al. manuscript “Evaluation of a Rapid, Generic Human Gestational Dose Model”

New Features

Enhancements

Bug Fixes

httk 2.0.4 (2021-05-10)

Enhancements

Bug Fixes

httk 2.0.3 (2020-09-25)

Enhancements

Bug Fixes

httk 2.0.2 (2020-07-19)

Enhancements

Bug Fixes

httk 2.0.1 (2020-03-02)

New Features

Enhancements

Bug Fixes

httk 2.0.0 (2020-02-17)

This version is consistent with consistent with Linakis et al. (submitted) “Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals”

New Features

Enhancements

httk 1.10.1 (2019-09-10)

Enhancements

Bug Fixes

version 1.10.0 (2019-07-12)

This version is consistent with the submitted manuscript Wambaugh et al.  “Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization”. Major enhancements were made to allow propagation of measurement-specific uncertainty and population variability into IVIVE predictions.

New Features

Enhancements

Bug Fixes

httk 1.9.2 (2019-04-22)

Bug Fixes

httk 1.9.1 (2019-04-15)

Bug Fixes

httk 1.9 (2019-02-04)

This version is consistent with the submitted version of Honda et al. “Using the Concordance of In Vitro and In Vivo Data to Evaluate Extrapolation Assumptions”

New Features

Enhancements

Bug Fixes

httk 1.8 (2018-01-23)

This version is consistent with the published version of Pearce et al.  “Evaluation and calibration of high-throughput predictions of chemical distribution to tissues”. This version contains calibrations for tissue:plasma partition coefficient calibration predictions.

New Features

Enhancements

Bug Fixes

httk 1.7 (2017-07-15)

This version is consistent with the JSS publication of Pearce et al. “httk: R Package for High-Throughput Toxicokinetics”.

Bug Fixes

httk 1.6 (2017-06-08)

This version includes data and modifications as reported in the recently submitted Pearce et al. paper “Evaluation and Calibration of High-Throughput Predictions of Chemical Distribution to Tissues”.

Enhancements

Bug Fixes

httk 1.5 (2017-03-02)

This version is consistent with Ring et al. “Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability”, which is accepted for publication at Environment International. Revisions include models, data, and vignettes for “httk-pop” functionality. “httk-pop” allows Monte Carlo simulation of physiological variability using data from the National Health and Nutrition Examination Survey.

New Features

Enhancements

Bug Fixes

httk 1.4 (2016-02-03)

This revision incorporates changes suggested by the reviewers of Pearce et al., which was accepted, pending minor revision, in the Journal of Statistical Software (now included in vignettes).

httk 1.3 (2015-10-14)

This revision adds ~200 more chemicals (from two recent publications including Wetmore et al. (2015) and make several small changes to improve usability and stability.

httk 1.2 (2015-05-11)

This version is consistent with a newly submitted article Pearce et al. “httk: R Package for High-Throughput Toxicokinetics” to the Journal of Statistical Software describing use of this package.

httk 1.1 (2015-03-06)

Initial public (CRAN) release (March 6, 2015).