Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines


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Documentation for package ‘nlmixr2est’ version 2.1.5

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A B C F G I N O P R S T V Y

-- A --

addCwres Add CWRES
addNpde NPDE calculation for nlmixr2
addTable Add table information to nlmixr2 fit object without tables
assertNlmixrFit Assert that this is a nlmixr2 fit object
assertNlmixrFitData Assert that this is a nlmixr2 fit data object
augPred.nlmixr2FitData Augmented Prediction for nlmixr2 fit

-- B --

boxCox Cox Box, Yeo Johnson and inverse transformation

-- C --

cholSE Generalized Cholesky Matrix Decomposition

-- F --

foceiControl Control Options for FOCEi

-- G --

getOfvType Set/get Objective function type for a nlmixr2 object
getValidNlmixrControl Get valid nlmixr control object
getValidNlmixrCtl Get valid nlmixr control object
getValidNlmixrCtl.default Get valid nlmixr control object
getValidNlmixrCtl.fo Get valid nlmixr control object
getValidNlmixrCtl.foce Get valid nlmixr control object
getValidNlmixrCtl.focei Get valid nlmixr control object
getValidNlmixrCtl.foi Get valid nlmixr control object
getValidNlmixrCtl.nlme Get valid nlmixr control object
getValidNlmixrCtl.posthoc Get valid nlmixr control object
getValidNlmixrCtl.rxSolve Get valid nlmixr control object
getValidNlmixrCtl.saem Get valid nlmixr control object
getValidNlmixrCtl.simulate Get valid nlmixr control object
getValidNlmixrCtl.simulation Get valid nlmixr control object
getValidNlmixrCtl.tableControl Get valid nlmixr control object

-- I --

iBoxCox Cox Box, Yeo Johnson and inverse transformation
iYeoJohnson Cox Box, Yeo Johnson and inverse transformation

-- N --

nlmeControl Control Values for nlme Fit with extra options for nlmixr
nlmixr nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2 nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2.function nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2.nlmixr2FitCore nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2.nlmixr2FitData nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2.rxUi nlmixr2 fits population PK and PKPD non-linear mixed effects models.
nlmixr2AllEst Show all the current estimation methods
nlmixr2AugPredSolve Augmented Prediction for nlmixr2 fit
nlmixr2CreateOutputFromUi Create nlmixr output from the UI
nlmixr2Est Generic for nlmixr2 estimation methods
nlmixr2Est.default Generic for nlmixr2 estimation methods
nlmixr2Est.fo Generic for nlmixr2 estimation methods
nlmixr2Est.foce Generic for nlmixr2 estimation methods
nlmixr2Est.focei Generic for nlmixr2 estimation methods
nlmixr2Est.foi Generic for nlmixr2 estimation methods
nlmixr2Est.nlme Generic for nlmixr2 estimation methods
nlmixr2Est.output Generic for nlmixr2 estimation methods
nlmixr2Est.posthoc Generic for nlmixr2 estimation methods
nlmixr2Est.predict Generic for nlmixr2 estimation methods
nlmixr2Est.rxSolve Generic for nlmixr2 estimation methods
nlmixr2Est.saem Generic for nlmixr2 estimation methods
nlmixr2Est.simulate Generic for nlmixr2 estimation methods
nlmixr2Est.simulation Generic for nlmixr2 estimation methods
nlmixr2Gill83 Get the optimal forward difference interval by Gill83 method
nlmixr2Hess Calculate Hessian
nlmixr2Logo Messages the nlmixr2 logo...
nlmixr2NlmeControl Control Values for nlme Fit with extra options for nlmixr
nlmixr2Validate Validate nlmixr2
nlmixr2Version Display nlmixr2's version
nlmixrAddObjectiveFunctionDataFrame Add objective function data frame to the current objective function
nlmixrAddTiming Manually add time to a nlmixr2 object
nlmixrCbind nlmixrCbind
nlmixrClone Clone nlmixr environment
nlmixrWithTiming Time a part of a nlmixr operation and add to nlmixr object
nmNearPD C++ implementation of Matrix's nearPD
nmObjGetControl Get control object from fit
nmObjGetControl.default Get control object from fit
nmObjGetControl.fo Get control object from fit
nmObjGetControl.foce Get control object from fit
nmObjGetControl.focei Get control object from fit
nmObjGetControl.foi Get control object from fit
nmObjGetControl.nlme Get control object from fit
nmObjGetControl.posthoc Get control object from fit
nmObjGetControl.saem Get control object from fit
nmObjGetEstimationModel Get the estimation model for a fit object depending on the object type
nmObjGetEstimationModel.default Get the ipred model for a fit object depending on the object type
nmObjGetEstimationModel.saem Get the ipred model for a fit object depending on the object type
nmObjGetFoceiControl Method for getting focei compatible control object from nlmixr object
nmObjGetFoceiControl.default Method for getting focei compatible control object from nlmixr object
nmObjGetFoceiControl.nlme Method for getting focei compatible control object from nlmixr object
nmObjGetFoceiControl.saem Method for getting focei compatible control object from nlmixr object
nmObjGetIpredModel Get the ipred model for a fit object depending on the object type
nmObjGetIpredModel.default Get the ipred model for a fit object depending on the object type
nmObjGetIpredModel.saem Get the ipred model for a fit object depending on the object type
nmObjGetPredOnly Get the pred-only model for a fit depending on the object type
nmObjGetPredOnly.default Get the pred-only model for a fit depending on the object type
nmObjGetPredOnly.saem Get the pred-only model for a fit depending on the object type
nmObjHandleControlObject Handle the control object
nmObjHandleControlObject.default Handle the control object
nmObjHandleControlObject.foceiControl Handle the control object
nmObjHandleControlObject.nlmeControl Handle the control object
nmObjHandleControlObject.saemControl Handle the control object
nmObjHandleModelObject Handle Model Object
nmObjHandleModelObject.default Handle Model Object
nmObjHandleModelObject.foceiModelList Handle Model Object
nmObjHandleModelObject.saemModelList Handle Model Object
nmObjUiSetCompressed Set if the nlmixr2 object will return a compressed ui
nmsimplex Nelder-Mead simplex search
nmTest Validate nlmixr2

-- O --

ofv Return the objective function

-- P --

print.saemFit Print an SAEM model fit summary

-- R --

residuals.nlmixr2FitData Extract residuals from the FOCEI fit

-- S --

saemControl Control Options for SAEM
setCov Set the covariance type based on prior calculated covariances
setOfv Set/get Objective function type for a nlmixr2 object
sqrtm Return the square root of general square matrix A
summary.saemFit Print an SAEM model fit summary

-- T --

tableControl Output table/data.frame options

-- V --

vpcSim VPC simulation

-- Y --

yeoJohnson Cox Box, Yeo Johnson and inverse transformation