Package: simtte
Title: Simulate Time-to-Event Data from PK/PD and Bespoke ODE Models
Version: 2.0.0
Language: en-US
Authors@R: person("Carlos", "Traynor", email = "carlos.traynor.qcp@gmail.com",
    role = c("aut", "cre"))
Description: Simulates time-to-event (survival) datasets for clinical trial
    design and analysis, including datasets driven by a joint
    pharmacokinetic/pharmacodynamic (PK/PD) model solved via the
    'mrgsolve' backend. Event times can be located directly during ODE
    integration ('in-solver' event detection) using a library of
    built-in PK/PD hazard models or a user-supplied 'mrgsolve' model
    converted for this purpose, or generated by inverse transform
    sampling from a closed-form Weibull or flexible M-spline baseline
    hazard, or from any externally simulated survival trajectory. See
    Bender et al. (2005) <doi:10.1002/sim.2059> for the inverse
    transform sampling methodology and Royston and Parmar (2002)
    <doi:10.1002/sim.1203> for flexible parametric survival models.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.0.0)
Imports: dplyr, magrittr, methods, mrgsolve, tools
Suggests: callr, testthat (>= 3.0.0), knitr, pkgload, rmarkdown,
        splines2, survival
VignetteBuilder: knitr
URL: https://github.com/csetraynor/simtte
BugReports: https://github.com/csetraynor/simtte/issues
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
RoxygenNote: 8.0.0
NeedsCompilation: no
Packaged: 2026-11-06 23:04:08 UTC; carlostraynor
Author: Carlos Traynor [aut, cre]
Maintainer: Carlos Traynor <carlos.traynor.qcp@gmail.com>
Repository: CRAN
Date/Publication: 2026-11-07 17:00:02 UTC
