Implements statistical methods for estimating disease penetrance in family-based studies. Penetrance refers to the probability of disease§ manifestation in individuals carrying specific genetic variants. The package provides tools for age-specific penetrance estimation, handling missing data, and accounting for ascertainment bias in family studies. Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.
| Version: | 0.1.0 |
| Depends: | R (≥ 3.5.0) |
| Imports: | clipp, stats, parallel, MASS, kinship2 (≥ 1.8.5), graphics, grDevices |
| Suggests: | knitr, rmarkdown, scales, ggplot2, roxygen2, testthat (≥ 3.0.0) |
| Published: | 2025-03-03 |
| DOI: | 10.32614/CRAN.package.penetrance |
| Author: | Nicolas Kubista [aut, cre], BayesMendel Lab [aut] |
| Maintainer: | Nicolas Kubista <bmendel at jimmy.harvard.edu> |
| License: | GPL-3 |
| URL: | https://github.com/nicokubi/penetrance, https://nicokubi.github.io/penetrance/ |
| NeedsCompilation: | no |
| SystemRequirements: | C++11 |
| Materials: | README |
| CRAN checks: | penetrance results |
| Reference manual: | penetrance.pdf |
| Vignettes: |
Simulation Study with penetrance (source, R code) Simulation study from empirical data with penetrance (source, R code) Penetrance Estimation with penetrance (source, R code) |
| Package source: | penetrance_0.1.0.tar.gz |
| Windows binaries: | r-devel: not available, r-release: penetrance_0.1.0.zip, r-oldrel: not available |
| macOS binaries: | r-devel (arm64): penetrance_0.1.0.tgz, r-release (arm64): penetrance_0.1.0.tgz, r-oldrel (arm64): penetrance_0.1.0.tgz, r-devel (x86_64): penetrance_0.1.0.tgz, r-release (x86_64): penetrance_0.1.0.tgz, r-oldrel (x86_64): penetrance_0.1.0.tgz |
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